- 1 stage of the Tour de France (1 in 2011)
- Milan-San Remo (3rd in 2008, 3rd in 2011)
- Gent-Wevelgem (3rd in 2010)
- Tour of Flanders (3rd in 2009, 3rd in 2010, 1st in 2017, 3rd in 2018)
- Paris-Roubaix (1st in 2019)
- Amstel Gold Race (1st in 2010, 1st in 2011, 1st in 2014, 1st in 2017)
- Liège-Bastogne-Liège (3rd in 2010, 1st in 2011)
- Giro di Lombardia (1st in 2009, 1st in 2010)
- Grand Prix Cycliste de Québec (1st in 2011)
- Grand Prix Cycliste de Montréal (3rd in 2011)
- La Flèche Wallonne (1st in 2011, 3rd in 2012)
- Clásica de San Sebastián (1st in 2011, 2nd in 2015)
- BinckBank Tour (2nd in 2011)
- E3 Harelbeke (2nd in 2017, 2nd in 2018)
- Omloop Het Nieuwsblad (1st in 2006, 1st in 2008)
- Strade Bianche (1st in 2011)
- Across Flanders (2nd in 2017)
- Four Days of Dunkirk (1st in 2022)
- Paris-Tours (1st in 2008, 1st in 2009)
| Tour de France | Stage | Rank |
|---|---|---|
| 2005 | 9 | 5th |
| 2005 | 16 | 5th |
| 2007 | 11 | 8th |
| 2008 | 1 | 2nd |
| 2011 | 1 | 1st |
| 2011 | 4 | 5th |
| 2011 | 5 | 2nd |
| 2011 | 6 | 7th |
| 2011 | 8 | 2nd |
| 2011 | 9 | 4th |
| 2011 | 13 | 10th |
| 2012 | Prologue | 9th |
| 2012 | 1 | 4th |
| 2012 | 13 | 8th |
| 2012 | 14 | 4th |
| 2013 | 3 | 5th |
| 2013 | 16 | 8th |
| 2017 | 14 | 4th |
| 2018 | 2 | 10th |
| 2018 | 5 | 3rd |
| 2018 | 9 | 4th |
21 Top 10 in the stages of the Tour de France.